Force-Frequency Relationship
نویسندگان
چکیده
منابع مشابه
Force-Frequency Relationship in the Failing Human Heart
a reduced force of contraction in vivo and in vitro. The present study was aimed to investigate whether inotropic stimulation influences the inverse force-frequency relationship in failing human myocardium. Methods and Results. The effects of the cAMP-independent positive inotropic agents ouabain (0.01 ,imol/L) and BDF 9148 (0.1 ,umol/L) as well as the 3-adrenoceptor agonist isoprenaline (0.01 ...
متن کاملThe force-frequency relationship: insights from mathematical modeling.
The force-frequency relationship has intrigued researchers since its discovery by Bowditch in 1871. Many attempts have been made to construct mathematical descriptions of this phenomenon, beginning with the simple formulation of Koch-Wesser and Blinks in 1963 to the most sophisticated ones of today. This property of cardiac muscle is amplified by β-adrenergic stimulation, and, in a coordinated ...
متن کاملPhospholamban-to-SERCA2 ratio controls the force-frequency relationship.
The force-frequency relationship (FFR) describes the frequency-dependent potentiation of cardiac contractility. The interaction of the sarcoplasmic reticulum Ca2+-adenosinetriphosphatase (SERCA2) with its inhibitory protein phospholamban (PLB) might be involved in the control of the FFR. The FFR was analyzed in two systems in which the PLB-to-SERCA2 ratio was modulated. Adult rabbit cardiac myo...
متن کاملPhospholamban: a major determinant of the cardiac force-frequency relationship.
The cardiac force-frequency relationship has been known for over a century, yet its mechanisms have eluded thorough understanding. We investigated the hypothesis that phospholamban, a potent regulator of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA), determines the cardiac force-frequency relationship. Isolated left ventricular papillary muscles from wild-type (WT) and phospholamban kn...
متن کاملHistorical Perspectives The force-frequency relationship: insights from mathematical modeling
Puglisi JL, Negroni JA, Chen-Izu Y, Bers DM. The forcefrequency relationship: insights from mathematical modeling. Adv Physiol Educ 37: 28–34, 2013; doi:10.1152/advan.00072.2011.—The force-frequency relationship has intrigued researchers since its discovery by Bowditch in 1871. Many attempts have been made to construct mathematical descriptions of this phenomenon, beginning with the simple form...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1973
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.33.6.665